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| Product Name | Recombinant Rat Gremlin-1 (Grem1) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 22.2kDa. Full Length of Mature Protein: 25-184aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Rattus norvegicus (Rat). Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Cysteine knot superfamily 1, BMP antagonist 1; Down-regulated in Mos-transformed cells protein; Cktsf1b1, Drm |
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| Gene, Accession, CAS # | Grem1, UniProt: O35793 |
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| Catalog # | RPC23825 |
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| Order / More Info | Recombinant Rat Gremlin-1 (Grem1) from BIOMATIK |
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| Product Specific References | n/a |
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