| 产品详情 |
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| Antigenic Specificity | MLH1 |
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| Clone | G168-15 |
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| Host Species | Mouse |
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| Reactive Species | rat, hamster, human |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IHC, IHC-P |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MLH1 Antibody (clone G168-15) LS-C95607. The G168-15 antibody recognizes the human and mouse MLH1 (80-85kDa. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. cross reacts with human, hamster and rat |
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| Immunogen | Full length recombinant MLH. |
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| Other Names | MLH1, COCA2, FCC2, HMLH1, HNPCC, HNPCC2, MutL protein homolog 1 |
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| Gene, Accession # | MLH1, Gene ID: 4292 |
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| Catalog # | LS-C95607 |
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| Price | |
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| Order / More Info | MLH1 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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