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| Product Name | PF 543 hydrochloride |
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| Description | Potent and selective SphK1 inhibitor (IC50 = 2 nM; Ki = 3.6 nM). Exhibits >100-fold selectivity for Sphk1 over Sphk2. Also exhibits >5,000 fold selectivity over S1P1-5 receptors and 48 protein and lipid kinases. Attenuates proliferation and induces necrosis in human colorectal cancer cells in vitro. Suppresses HCT-116 tumor xenograft growth in mice. Purity 98%. MW (observed): 502.07 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2R)-1-[[(4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol hydrochloride |
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| Gene, Accession, CAS # | CAS: 1706522-79-3 |
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| Catalog # | 5754/10 |
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| Price | |
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| Order / More Info | PF 543 hydrochloride from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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