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| Product Name | Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 4 (Map2k4) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 60kDa. Full Length of Mature Protein: 2-397a. N-terminal 6xHis-SUMO-tagged. Mus musculus (Mouse). Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 ses to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | C-JUN N-terminal kinase kinase 1; JNK kinase 1; JNKK 1JNK-activating kinase 1MAPK/ERK kinase 4; MEK 4SAPK/ERK kinase 1; SEK1 |
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| Gene, Accession, CAS # | Map2k4, UniProt: P47809 |
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| Catalog # | RPC21643 |
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| Order / More Info | Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 4 (Map2k4) from BIOMATIK |
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| Product Specific References | n/a |
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