| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Numb |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human, mouse, chicken |
|---|
| Isotype | n/a |
|---|
| Format | immunogen affinity purified |
|---|
| Size | 0.1 ml |
|---|
| Concentration | 3.5 mg/ml |
|---|
| Applications | Western Blot, Simple Western, Immunocytochemistry/Immunofluorescence. This NUMB antibody is useful for Western blot and Immunocytochemistry/Immunofluorescence. In WB one may see any or all of the four isoforms. The molecular weight of human and mouse NUMB is 72 kDa (isoform 1), 66 kDa (isoform 2), 71 kDa (isoform 3), and 65 kDa (isoform 4). Multiple non-specific bands may be seen with lower dilutions and/or longer exposure times than suggested in the protocol we used to obtain our data. In Simple Western only 10 - 15 uL of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue. |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The Numb Antibody from Novus Biologicals is a rabbit polyclonal antibody to Numb. This antibody reacts with human, mouse, chicken. The Numb Antibody has been validated for the following applications: Western Blot, Simple Western, Immunocytochemistry/Immunofluorescence. This is specific for all four isoforms of the NUMB protein. Numb is a transmembrane signaling receptor that is activated by the DSL family of ligands. Studies suggest that mammalian Numb plays a role in progenitor cell fate in neurogenesis. Numb exerts its role on cell fate by antagonizing Notch signaling. The mammalian Numb gene undergoes alternative splicing to produce at least four functionally different Numb isoforms which regulate different processes. A loss of Numb expression has been demonstrated in breast cancer, non-small cell lung cancer and chronic myelogenous leukemia. |
|---|
| Immunogen | A synthetic peptide made to a C-terminal region of mouse NUMB (between residues 600-653). [UniProt# Q9QZS3] |
|---|
| Other Names | h-Numb, numb (Drosophila) homolog, numb homolog (Drosophila), protein numb homolog, Protein S171, S171 |
|---|
| Gene, Accession # | NUMB, Gene ID: 8650 |
|---|
| Catalog # | NB500-178 |
|---|
| Price | |
|---|
| Order / More Info | Numb Antibody from NOVUS BIOLOGICALS, LLC |
|---|
| Product Specific References | PubMed: 27889896 |
|---|
| 产品资料 |
|
|