| 产品详情 |
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| Product Name | Go 6976 |
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| Description | Purity >98%. Go 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKCAlpha and PKCBeta1, respectively. It does not inhibit the activity of PKCDelta, PKCe, or PKCGamma (IC50 s > 3 µM), indicating a preference for the Ca2+ -dependent subtypes, PKCAlpha and PKCBeta1. Go 6976 also inhibits the checkpoint kinases Chk1/2. It was shown to abrogate DNA damage-induced S- and G2 -phase cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5,6,7,13-tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile, PD 406976 |
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| Gene, Accession, CAS # | CAS: 136194-77-9 |
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| Catalog # | LS-H7978 |
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| Order / More Info | Go 6976 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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