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| Product Name | Recombinant Human Kininogen-1 (KNG1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 31.8kDa. Partial: 390-639aa. N-terminal 6xHis-tagged. Homo sapiens (Human). 1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Alpha-2-thiol proteinase inhibitorFitzgerald factorHigh molecular weight kininogen; HMWKWilliams-Fitzgerald-Flaujeac factor |
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| Gene, Accession, CAS # | KNG1, UniProt: P01042 |
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| Catalog # | RPC24339 |
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| Order / More Info | Recombinant Human Kininogen-1 (KNG1), partial from BIOMATIK |
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| Product Specific References | n/a |
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