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| Product Name | Recombinant Human Protein arginine N-methyltransferase 1 (PRMT1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 55.3kDa. Partial: 1-248aa. N-terminal GST-tagged. Homo sapiens (Human). Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Histone-arginine N-methyltransferase PRMT1 (EC:2.1.1.125)Interferon receptor 1-bound protein 4 |
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| Gene, Accession, CAS # | PRMT1, UniProt: H7C2I1 |
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| Catalog # | RPC24021 |
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| Order / More Info | Recombinant Human Protein arginine N-methyltransferase 1 (PRMT1), partial from BIOMATIK |
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| Product Specific References | n/a |
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