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| Product Name | Recombinant Rat M-CSF (carrier-free) |
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| Description | M-CSF was first characterized as a glycoprotein that induces monocyte and macrophage colony formation from precursors in murine bone marrow cultures. M-CSF is constitutively present at biologically active concentrations in human serum, and binds CD14+ monocytes, and promotes the survival and proliferation of peripheral blood monocytes. In addition, M-CSF enhances monocyte functions such asphagocytic activity, microbial killing, and tumor cell cytotoxicity. It also induces the synthesis of inflammatory cytokines such as IL-1-β, TNF-α, and INF-γ in monocytes. M-CSF induces RANKL in mature osteoclasts, and is consequently a potent stimulator of mature osteoclast resorbing activity. Also, M-CSF induces VEGF in monocytes in human tumors. High levels of M-CSF, mononuclear phagocytes, and VEGF are associated with poor prognosis in patients with cancer. High levels of M-CSF have also been correlated to other pathologies such as pulmonary fibrosis and atherosclerosis. M-CSF binds to its receptor M-CSFR, and this receptor is shared with another ligand, IL-34. Human M-CSF and IL-34 exhibit cross-species specificity by both binding to the human and mouse M-CSF receptors. Respectively, rat M-CSF has 80% and 77% identity with mouse and human M-CSF. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | CSF1, CSF-1, MCSF |
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| Gene, Accession, CAS # | Gene ID: 78965 |
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| Catalog # | 556908 |
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| Order / More Info | Recombinant Rat M-CSF (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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