| 产品详情 |
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| Product Name | Mocetinostat |
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| Description | Purity >98%. Mocetinostat is an orally available inhibitor of histone deacetylases (HDACs) that selectively targets HDAC1 and 2 (IC50 s = 0.15 and 0.29 µM, respectively), less potently inhibits HDAC3 and 11 (IC50 s = 1.66 and 0.59 µM, respectively) and has negligible actions against HDAC4-8. It induces hyperacetylation of histones, causes cell cycle blockade, and induces apoptosis in cancer cells in vitro . Mocetinostat also has antitumor activity in vivo, blocking the growth of human tumor xenografts in mice. It also significantly reduces cardiac fibrosis following ischemic heart failure in mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-benzamide, MGCD0103 |
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| Gene, Accession, CAS # | CAS: 726169-73-9 |
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| Catalog # | LS-H8786 |
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| Order / More Info | Mocetinostat from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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