| 产品详情 |
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| Product Name | Semagacestat |
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| Description | Purity >98%. Gamma-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and Beta-amyloid precursor protein (APP), within the transmembrane domain. Semagacestat is a potent inhibitor of Gamma-secretase that blocks the production of ABeta38, ABeta40, and ABeta42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively. It also blocks Notch signaling (IC50 = 14.1 nM). Semagacestat modulates Gamma-secretase activity in vivo, altering ABeta levels in brain, cerebrospinal fluids, and plasma in a dose-dependent fashion. Although semagacestat does not improve cognitive status in humans, it is useful as a pan Gamma-secretase inhibitor for research purposes. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2S)-2-hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-butanamide, LY450139 |
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| Gene, Accession, CAS # | CAS: 425386-60-3 |
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| Catalog # | LS-H9894 |
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| Price | |
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| Order / More Info | Semagacestat from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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