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| Product Name | Human EGFR Protein (Recombinant His, C-terminal tag) |
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| Description | Purity >95% by non-reducing SDS-PAGE and HPLC, MW: 80 kDa (SDS-PAGE). Epidermal Growth Factor Receptor (EGFR) belongs to a family of tyrosine kinase receptors including Human EGF Receptors (HER) 2, 3, and 4 which all play important roles in cell growth and differentiation. Their primary ligands are EGF, Heparin-Binding EGF and Transforming Growth Factor Alpha. Upon ligand binding, EGFR undergoes asymmetric dimerization, composed of an 'activator' and a 'receiver'. EGFR and its family members are disregulated in numerous cancers. In particular, EGFR is overexpressed in many epithelial solid tumors. Evidence suggests EGFR is an excellent target for pharmacologic intervention in Non Small Cell Lung Cancer (NSCLC) due to its high level of expression and prominent role in tumor growth and metastasis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | EGFR, EGF Receptor, ERBB, ERBB1, MENA, PIG61, Proto-oncogene c-ErbB-1, V-erb-b homolog, EGF-R, HER1 |
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| Gene, Accession, CAS # | EGFR, Gene ID: 1956 |
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| Catalog # | LS-G27245 |
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| Order / More Info | Human EGFR Protein (Recombinant His, C-terminal tag) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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