| 产品详情 |
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| Product Name | Recombinant Mouse IL-34 (carrier-free) |
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| Description | Mouse IL-34 shares a sequence identity of 71% with human IL-34 on the amino acid level, and the IL-34 gene is syntenic in the human, chimpanzee, rat, and mouse genomes. IL-34 has no apparent consensus structural domain or motif and does not share sequence homology with M-CSF; nevertheless, it binds to the CSFR. These two cytokines are not identical in biological activity and signal activation. IL-34 and CSF show an equivalent ability to support cell growth or survival. However, these cytokines have different ability to induce the production of chemokines (MCP-1 and eotaxin-2) in primary macrophages, the morphological change in TF-1-fms cells, and the migration of J774A.1 cells. The use of monoclonal antibodies against the CSFR suggests a differential domain binding in the receptor to IL-34 and CSF. As a result, different bioactivities and signal activation kinetics/strength are produced for these cytokines. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | IL34, C16orf77 homolog |
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| Gene, Accession, CAS # | Gene ID: 762577 |
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| Catalog # | 577606 |
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| Price | |
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| Order / More Info | Recombinant Mouse IL-34 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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