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| Product Name | Recombinant Mouse IL-6 (carrier-free) |
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| Description | IL-6 is a multifunctional cytokine that can regulate various immune and inflammatory responses. Several studies have suggested a crucial role for IL-6 in angiogenesis. The use of mice deficient in IL-6 (-/-) demonstrated a critical role for this protein in a mouse model of lung angiogenesis. IL-6 has been shown to cause proliferation and migration of systemic endothelial cells in culture (1). The classical responsiveness to IL-6 is governed by a receptor complex consisting of two membrane-bound subunits, an 80-kD cognate chain (IL-6R), and a ubiquitously expressed 130-kD β-chain receptor (gp130) which acts as the universal signal-transducing element for all IL-6 family cytokines (2). Alternatively, IL-6 regulation of leukocyte trafficking relies upon signaling via its soluble IL-6R (termed IL-6 trans-signaling) (3). IL-6 plays a major role in regulating neutrophil clearance during acute peritoneal inflammation; as a result of specific down-regulation of neutrophil-attracting chemokine (CXCL1/KC) production (4). IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Treg differentiation by inhibition of TGF-beta induced Foxp3 and induction of RORgammat, a Th17 lineage-specific transcription factor (5). |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Interleukin-6, Interferon-b2, BSF-2, CDF, HSF, HPGF |
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| Gene, Accession, CAS # | Gene ID: 16193 |
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| Catalog # | 575702 |
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| Order / More Info | Recombinant Mouse IL-6 (carrier-free) from BIOLEGEND |
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| Product Specific References | PubMed: 20530256,21321188,21771795,22219321,24944284 |
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