| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Mouse IL-6 (carrier-free) |
|---|
| Description | IL-6 is a multifunctional cytokine that can regulate various immune and inflammatory responses. Several studies have suggested a crucial role for IL-6 in angiogenesis. The use of mice deficient in IL-6 (-/-) demonstrated a critical role for this protein in a mouse model of lung angiogenesis. IL-6 has been shown to cause proliferation and migration of systemic endothelial cells in culture (1). The classical responsiveness to IL-6 is governed by a receptor complex consisting of two membrane-bound subunits, an 80-kD cognate chain (IL-6R), and a ubiquitously expressed 130-kD β-chain receptor (gp130) which acts as the universal signal-transducing element for all IL-6 family cytokines (2). Alternatively, IL-6 regulation of leukocyte trafficking relies upon signaling via its soluble IL-6R (termed IL-6 trans-signaling) (3). IL-6 plays a major role in regulating neutrophil clearance during acute peritoneal inflammation; as a result of specific down-regulation of neutrophil-attracting chemokine (CXCL1/KC) production (4). IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Treg differentiation by inhibition of TGF-beta induced Foxp3 and induction of RORgammat, a Th17 lineage-specific transcription factor (5). |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | Interleukin-6, Interferon-b2, BSF-2, CDF, HSF, HPGF |
|---|
| Gene, Accession, CAS # | Gene ID: 16193 |
|---|
| Catalog # | 575706 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Mouse IL-6 (carrier-free) from BIOLEGEND |
|---|
| Product Specific References | PubMed: 20530256,21321188,21771795,22219321,24944284 |
|---|
| 产品资料 |
|
|