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| Product Name | Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 56.7kDa. Partial: 138-499aa. N-terminal 6xHis-B2M-tagged. Homo sapiens (Human). Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | CDC-like kinase 2 |
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| Gene, Accession, CAS # | CLK2, UniProt: P49760 |
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| Catalog # | RPC21106 |
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| Price | |
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| Order / More Info | Recombinant Human Dual specificity protein kinase CLK2 (CLK2), partial from BIOMATIK |
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| Product Specific References | n/a |
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