| 产品详情 |
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| Antigenic Specificity | TP / Thymidine Phosphorylase |
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| Clone | TYMP/2890R |
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| Host Species | Recombinant Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | Protein A/G purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IHC-Fx |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | TP / Thymidine Phosphorylase Antibody (clone TYMP/2890R) LS-C751118. Recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites |
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| Immunogen | Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein. Antigen Molecular Weight: 55 kDa |
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| Other Names | TYMP, ECGF1, HPD-ECGF, MEDPS1, MNGIE, MTDPS1, PD-ECGF, Thymidine phosphorylase, PDECGF, ECGF, Gliostatin, TdRPase, TP |
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| Gene, Accession # | TYMP, Gene ID: 1890 |
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| Catalog # | LS-C751118 |
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| Price | |
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| Order / More Info | TP / Thymidine Phosphorylase Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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