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| Product Name | Recombinant Human CCL3L1/ MIP-1α isoform LD78-β (carrier-free) |
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| Description | CCL3L1 is a chemokine belonging to the CC chemokine family. The gene locus is located on q-arm of Chromosome 17 where a chemokine gene cluster is positioned. CCL3L1 shows a high degree of structural and functional similarity to CCL3 and it might arise by segmental gene duplication. CCL3L1 encodes MIP-1α isoform LD78-β, which shows a high affinity to CCR5 expressed in T cells. CCL3L1 can chemoattract monocytes as well. It has showed that CD26/ dipeptidyl peptides IV can process N-terminus of CCL3L1 into other two forms, LD78-β (3-70) and LD78-β (5-70). Particularly, LD78-β (3-70) is abundant from peripheral blood mononuclear cells and has increased chemotactic activity comparing the full length. Several evidence show that the copy number of CCL3L1 varies among different individuals (1-6 copies). The copy number of CCL3L1 has been studied in several diseases, such as Rheumatoid arthritis (RA), HIV infection, and Kawasaki disease. Previous reports indicated that CCL3L1 is a potent inhibitor of HIV infection since CCR5 is co-receptor for R5 strain of HIV. However, there are conflicting data whether the copy number of CCL3L1 affects disease susceptibility. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | C-C motif chemokine ligand 3-like 1 (CCL3L1), LD78-beta, G0/G1 switch regulatory protein 19-2, G0S19-2, PAT 464.2, Small-inducible cytokine A3-like 1, Tonsillar lymphocyte LD78 beta protein, SCYA3L1 |
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| Gene, Accession, CAS # | Gene ID: 6349 |
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| Catalog # | 719204 |
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| Order / More Info | Recombinant Human CCL3L1/ MIP-1α isoform LD78-β (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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