| 产品详情 |
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| Product Name | Atpenin A5 |
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| Description | Purity ≥95% (HPLC). Antibiotic. Antifungal. Potent and specific mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor. Mitochondrial ATP-sensitive potassium (mK(ATP)) channel activator. Cardioprotective. Modulates mitochondrial ROS generation during cardioprotection. The IC50 value against bovine heart complex II is 3.6nM (which is ~300-fold lower than the IC50 value of carboxin (1.1uM)). It also inhibits fumarate reductase of Ascaris suum (IC50 = 12nM). Inhibition of E. coli succinate dehydrogenase is less potent (IC50 = 5uM). By co-crystallization studies of atpenin A5 and complex II, the binding site of atpenin A5 was found to be the quinone-binding site of complex II. Additionally, atpenin A5 has been shown to have a protective action against ischemia-reperfusion via the activation of mitochondrial KATP channels. Synonyms: 3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone |
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| Size | 250ug, 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone |
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| Gene, Accession, CAS # | CAS: 119509-24-9 |
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| Catalog # | 44573 |
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| Order / More Info | Atpenin A5 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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