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| Product Name | AGER, Recombinant, Human, aa23-342, His-Tag (Advanced Glycosylation End Product-specific Receptor) |
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| Description | Purity ~90% (SDS-PAGE). Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the Extracellular domain to the intracellular space in cor |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q15109 |
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| Catalog # | 372173 |
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| Order / More Info | AGER, Recombinant, Human, aa23-342, His-Tag (Advanced Glycosylation End Product-specific Receptor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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