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| Product Name | Cetuximab (Erbitux®) BioAssay™ ELISA Kit |
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| Description | Cetuximab (Erbitux®) is a chimeric IgG1 monoclonal antibody that binds the extracellular domain of the epidermal growth factor receptor (EGFR). It is a 152kD molecule composed of four polypeptide chains: two identical heavy chains and two identical light chains, consisting of 449 and 214 amino acids, respectively, bound by covalent and non-covalent bonds. The bond with EGFR is characterized by a higher affinity than either endogenous ligand, as epidermal growth factor (EGF), or transforming growth factor alpha. This binding inhibits activation of the receptor tyrosine kinase and the associated downstream signaling that includes the mitogenactivated protein kinase, phosphoinositide 3-kinase/Akt and the Janus kinases/ signal transducers and activator of transcription (Stat) pathways. Furthermore Cetuximab induces antibody-mediated receptor dimerization, internalization and degradation leading to receptor down-regulation. In addition, it exhibits antibody-dependent cellular cytotoxicity t |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 384860 |
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| Order / More Info | Cetuximab (Erbitux®) BioAssay™ ELISA Kit from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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