| 产品详情 |
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| Product Name | Herg Activator |
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| Description | Purity ~97% (HPLC). A diphenolurea compound that selectively activates human ether-a-go-go-related gene (hERG) K+-channel (EC50=10.5uM). Shown to significantly increase both steady-state and peak tail currents of hERG channels, but exhibits only a trivial effect on Kv4.3 and Kv1.5 channels. Causes a significant reduction in action potential duration (APD90) in patch clamp assays in Xenopus oocytes, HEK293 cells, and guinea pig cardiamyocyes that can be reversed by the addition of E-4031, a specific blocker of hERG channels. Also shown to activate IKr channel in cardiomyocytes and increase post-repolarization refractory time thereby alleviating hyper-excitability and producing antiarrhythmic effects. It can also restore IKr reduced by down-regulation of IKr expression. Formula: C15H10F6N2O3 Molecular Weight: 380.2 Solubility: DMSO (100mg/ml, clear, nearly colorless solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Herg Activator (NS1643, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea, Human ether-a-go-go related gene (hERG) K+ channel activator, KV11.1 Channel Activator) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217419 |
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| Price | |
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| Order / More Info | Herg Activator from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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