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| Product Name | GSK3 alpha, Recombinant, Human, GST-Tag (Glycogen Synthase Kinase 3 alpha) |
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| Description | Purified (~70-90%). GSK3alpha is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and transcription factors (e.g., JUN). GSK3alpha also plays a role in the WNT and PI3K signaling pathways. Alzheimer disease is associated with increased production and aggregation of amyloid-beta-40 and -42 peptides into plaques. GSK3alpha is required for maximal production of the beta-amyloid-40 and -42 peptides generated from the amyloid precursor protein by presenilin-dependent gamma-secretase cleavage. In vitro, lithium, a GSK3alpha inhibitor, blocks the production of the beta-amyloid peptides by interfering with the gamma-secretase step. Source: Recombinant protein corresponding to human GSK3 alpha fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~81kD Specific Activity: 184nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_019884 |
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| Catalog # | 500055 |
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| Order / More Info | GSK3 alpha, Recombinant, Human, GST-Tag (Glycogen Synthase Kinase 3 alpha) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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