| 产品详情 |
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| Product Name | GSK-3beta Inhibitor XXIV |
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| Description | Purity ~98% (HPLC). An orally bioavailable and blood-brain-barrier permeable oxadiazolo-benzofuranylphenylsulfoxide compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3b (IC50=35nM, 34 and 140nM for racemic, (S)-9b eutomer and (R)-9b distomer). The (S)-9b eutomer displays excellent selectivity (IC50 > 10uM) over Cdk1/2/5, Chk1, p38a, JNK1, MEKK1, IKKb, PKCth, CK1d, EGFR, ErbB2, Src, Lck, IR, Tie2, c-Kit, c-Met, VEGFR2, FGFR3 and PDGFRa/b, and lowers tau phosphorylation at GSK-3b-Thr205 in a CWS (cold water stress) mouse model (3mg/kg, p.o.) Formula: C18H14N2O3S Solubility: DMSO or EtOH Molecular Weight: 338.4 |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GSK-3beta Inhibitor XXIV (2-Methyl-5-(3-[4-(methylsulfinyl)phenyl)-1-benzofuran-5-yl)-1,3,4-oxadiazole, Racemic) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217402 |
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| Order / More Info | GSK-3beta Inhibitor XXIV from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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