| 产品详情 |
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| Product Name | GSK-3 beta Inhibitor XXVII |
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| Description | Purity ~99% (HPLC). A cell-permeable pyridinylpyrazinecarboxamide compound that acts as a highly potent, reversible, and ATP-competitive inhibitor of GSK-3b (Ki=4.9nM) with ~110-fold greater selectivity over Cdk2 (Ki=540nM). Shows only a trivial effect on the activities of 26-related kinases at much higher doses. Blocks GSK-3b-mediated phosphorylation of Ser396 in stably transfected 3T3 fibroblasts expressing four-repeat tau protein (IC50=76nM). Readily crosses blood-brain barrier and exhibits desirable bioavailability and aqueous solubility. Formula: C21H23N7O3S• 2.5 HC · 5H2O Primary Target: GSK-3b Solubility: DMSO Molecular Weight: 634.8 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GSK-3 beta Inhibitor XXVII (3-Amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, HCl) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217400 |
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| Price | |
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| Order / More Info | GSK-3 beta Inhibitor XXVII from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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