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| Product Name | GSK-J5 Hydrochloride |
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| Description | GSK-J5 Hydrochloride is a selective jumonji H3K27 demethylase inhibitor that modulates the proinflammatory macrophage response. The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.1,2 GSK-J4 (Item No. 12073) is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1 (Item No. 12054), an inhibitor of JMJD3. GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base.3 However, the free base is a weak inhibitor of JMJD3 (IC50 > 100 µM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition.3 |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanineEthyl Ester Hydochloride |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 164333 |
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| Order / More Info | GSK-J5 Hydrochloride from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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