| 产品详情 |
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| Product Name | DMH-1 |
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| Description | Selective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC50 = 108 nM [Hao et al., 2010] or 12.6 nM [Mohedas et al., 2013] in in vitro kinase assays). Exhibits 6- and 19-fold selectivity for ALK-2 over ALK-1 and ALK-3, respectively, and no significant inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614). Purity 98%. MW (observed): 380.44 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline |
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| Gene, Accession, CAS # | CAS: 1206711-16-1 |
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| Catalog # | 4126/50 |
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| Price | |
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| Order / More Info | DMH-1 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 23563587, 23928500, 25579684, 25806427, 26110906, 26215036, 26655496, 27320041 |
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