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| Product Name | Apolipoprotein H, aa1-345, Recombinant, Human (beta 2 Glycoprotein 1, ApoHb2gp1) |
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| Description | Purity ~95% (SDS-PAGE). Apolipoprotein H (ApoH), is a 50kD variably glycosylated member of the complement control superfamily of proteins (1, 2). Mature human ApoH consists of four tandem Sushi/SCR repeats followed by one Sushi-like repeat (3, 4). Mature human ApoH shares 76%, 82% aa sequence identity with mouse and rat ApoH, respectively. Hepatocyte- derived ApoH binds directly to negatively charged phospholipids (5). It circulates as a component of lipoprotein particles and as a lipid-free serum protein (6). ApoH also associates with liposomes and apoptotic cell debris, thereby enabling their renal clearance via Megalin uptake (7, 8). Circulating levels of ApoH are postively correlated with triglyceride-rich lipoprotein (VLDL) components in type II diabetes (9). ApoH inhibits thrombosis by blocking the activation of Coagulation Factor XI but also shows procoagulant activity by inhibiting the activation of Protein C (10, 11). ApoH can be cleaved by Plasmin at Lys317-Thr318, an action |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P02749 |
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| Catalog # | A2299-77Q |
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| Order / More Info | Apolipoprotein H, aa1-345, Recombinant, Human (beta 2 Glycoprotein 1, ApoHb2gp1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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