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| Product Name | Neuronal Endopeptidase, Rat (DINE, ECEL1) (Control Peptide) |
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| Description | Highly purified. A 17-aa peptide sequence, mapping nears the cytoplasmic N-terminus of rat DINE. The amyloid beta-peptide (Ab) of 39 to 43aa (Ab40, Ab42, Ab43) is constitutively produced in brain upon proteolysis of the b-amyloid precursor protein (APP). In the young and healthy humans, Ab is rapidly catabolized before it can be deposited in the brain. However, upon aging or the onset of familial Alzheimer's Disease, alterations in either synthesis or degradation/clearance of Ab may contribute to amyloid depositions in the brain. Ab is susceptible to a number of in vivo and in vitro proteases like cathepsin-D and M-13 metalloproteases. The M-13 family includes several members of zinc-dependent proteases like damage-induced neuronal endopeptidase (DINE), product of phosphate regulating gene with homologies to endopeptidases on the X chromosome (PHEX), neutral endopeptidase 24.11 or neprilysin (NEP) and neprilysin-like proteases (NEPLs). NEPLs (alpha, -beta, gamma) arise from the alterna |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | N2174-50 |
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| Order / More Info | Neuronal Endopeptidase, Rat (DINE, ECEL1) (Control Peptide) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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