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| Product Name | sRANK Ligand, Recombinant, Rat |
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| Description | Purity ~98% (SDS-PAGE). RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naive T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansive osteolysis and Paget disease of bone (PDB2). Recombinant rat sRANKL is a polypeptide comprising the TNF homologous region of RANKL (174aa residues). Source: Recombinant protein corresponding to 174aa residues from rat sRANK Liga |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | sRANK Ligand, Recombinant, Rat (TNFRSF11A, ODFR, Osteoclast Differentiation Factor Receptor, ODAR, Osteoclast Differentiation and Activation Receptor, TRANCE Receptor) |
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| Gene, Accession, CAS # | TNFRSF11, Gene ID: 4982, Accession: O00300 |
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| Catalog # | 220279 |
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| Order / More Info | sRANK Ligand, Recombinant, Rat from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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