| 产品详情 |
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| Product Name | SKP2 E3 Ligase Inhibitor I, C1 |
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| Description | Purity ~99% (HPLC). A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10uM for 16h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) complex. Shown to inhibit the proliferation of human breast cancer MCF-7 and melanoma 501 Mel cells (IC50 = 8 and 30uM, respectively; 16h incubation). Unlike SMIP004, C1 does not affect cellular Cyclin E/CDK2 kinase activity or Skp2 level. Solubility: DMSO Primary Target: disrupts p27-Skp2 interaction Molar Mass: 465.3 |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SKP2 E3 Ligase Inhibitor I, C1 (p21/Cip1/Waf1 Activator I; p27/Kip1 Activator I, S-phase Kinase-associated Protein 2 Inhibitor I; SCFSKP2 Inhibitor I, CRL1SKP2 Inhibitor I, (Z)-2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic Acid) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217794 |
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| Order / More Info | SKP2 E3 Ligase Inhibitor I, C1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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