| 产品详情 |
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| Product Name | SKP2 E3 Ligase Inhibitor II, SMIP004 |
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| Description | Purity ~99% (HPLC). A cell-permeable phenylacetamide compound that is shown to upregulate p21Cip1/Waf1 and/or p27Kip1 in prostate cancer LNCaP, PC3, DU145, but not HeLa, cultures (40uM for 24h) with a concomitant downregulation of the F-box E3 ubiquitin ligase Skp2 and a delayed G1-to-S cell cycle transition, displaying no apparent effect toward cell cycle progression or p21 and p27 levels in non-cancer human fibroblast IMR90. SMIP004 antiproliferative activity against LNCaP, PC3, DU145 soft agar colony formation is mainly cytostatic with cytotoxicity observed only in LNCaP cultures at high concentrations (IC50 = 40uM in 72h), but not PC3 or DU145 even at concentrations as high as 80uM and for up to 96h. Solubility: DMSO Molar Mass: 205.30 |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SKP2 E3 Ligase Inhibitor II, SMIP004 (CRL1SKP2 Inhibitor II, p21/Cip1/CKI/Waf1 Activator II, N-(4-Butyl-2-methylphenyl)acetamide, p27/Kip1 Activator II, S-phase Kinase-associated Protein 2 Inhibitor II, SCFSKP2 Inhibitor II, Small Molecule Inhibitor of p27 Depletion 004) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217795 |
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| Order / More Info | SKP2 E3 Ligase Inhibitor II, SMIP004 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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