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| Product Name | IL-2sR alpha BioAssay™ ELISA Kit (Human) |
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| Description | The biological effects of interleukin 2 (IL-2) are mediated by its binding to a multi-chain cellular receptor complex. The IL-2 receptor (IL-2 R) complex consists of three glycoprotein chains. The alpha chain (IL-2 R alpha/CD25) and beta chain (IL-2 R beta/CD122) act together with the gamma chain (IL-2 R gamma/CD132) to form a high affinity receptor that transduces the signal upon IL-2 binding. A soluble form of CD25/IL-2 R alpha is present in the serum in parallel with its increased cellular expression. There are reports of soluble IL-2 R beta as well. The biologic function of soluble CD25/IL-2 R alpha is unclear because, due to its low affinity, it is expected to be a poor inhibitor of IL-2. CD25/IL-2 R alpha is a precursor type I membrane protein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. Studies suggest a correlation between the levels of CD25/IL-2 R alpha in serum with the onset of rejection in allograft recipients, with autoi |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | IL-2sR alpha BioAssay™ ELISA Kit (Human) (Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, CD25, IL2RA, IL-2Ralpha, IL2Ralpha) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 360512 |
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| Order / More Info | IL-2sR alpha BioAssay™ ELISA Kit (Human) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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