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| Product Name | Noggin, Human (Nog) |
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| Description | Purity ~95% (SDS-PAGE). Noggin is a glycoprotein predominantly expressed by the dorsal mesoderm during embryogenesis and is secreted as a covalently linked homodimer. Noggin is essential for cartilage morphogenesis and joint formation. It is an inhibitor of bone morphogenic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Defects in Noggin are a cause of symphalangism proximal syndrome (SYM1), of multiple synostoses syndrome 1 (SYNS1), of the tarsal-carpal coalition syndrome (TCC), of stapes ankylosis with broad thumb and toes, and of brachydactyly type B2 (BDB2). Source: Noggin, from Human DNA sequence encoding human Noggin protein (containing the signal peptide sequence and the mature human noggin sequence) was expressed in modified human 293 cells. Molectular Weight: ~25kD-30kD with post-translation modification and ~23kD unmodified |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q13253 |
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| Catalog # | 215404 |
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| Order / More Info | Noggin, Human (Nog) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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