| 产品详情 |
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| Product Name | TRPV4 Antagonist II, HC-067047 |
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| Description | Purity ~98% (HPLC). A pyrrolocarboxamide compound that potently antagonizes TRP (transient receptor potential) family cation channel TRPV4 activity (IC50 = 17, 48, and 133nM, respectively, against mouse, human, or rat TRPV4 in whole cell voltage-gated current measurement) in a reversible manner, displaying much reduced potency against human ERG and TRPM8 (IC50 = 368 and 780nM, respectively) and little or no activity toward hKv1.3, hTRPA1, hTRPC5, hTRPV1/2/3/6, mTRPM7, mTRPV2, or rKv1.2. HC-067047 is efficacious (10mg/kg via i.p.) in reducing micturition (urination) frequency and increasing voided urine volume of mice and rats suffering from CPA-induced cystitis in vivo. Formula: C26H28F3N3O2 Molecular Weight: 471.5 Solubility: DMSO (50mg/ml, clear, colorless solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TRPV4 Antagonist II, HC-067047 (2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217853 |
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| Order / More Info | TRPV4 Antagonist II, HC-067047 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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