| 产品详情 |
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| Antigenic Specificity | CDH1 / E Cadherin |
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| Clone | rCDH1/1525 |
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| Host Species | Recombinant Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | Protein A/G purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IHC-Fx, PMA, SDS-PAGE, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CDH1 / E Cadherin Antibody (clone rCDH1/1525) LS-C751498. Recognizes a protein of 120-80 kDa , identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma. Does not react with: Mouse, Rat |
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| Immunogen | Recombinant full-length human E-Cadherin protein. Antigen Molecular Weight: 120-80 kDa (Mature) - 135 kDa (Precursor) |
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| Other Names | CDH1, CD324, CDHE, Cell-CAM 120/80, E Cadherin, E-Cadherin, ECAD, Epithelial cadherin, Arc-1, UVO, Cadherin-1, CAM 120/80, CD324 antigen, LCAM, Uvomorulin |
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| Gene, Accession # | CDH1, Gene ID: 999 |
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| Catalog # | LS-C751498 |
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| Price | |
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| Order / More Info | CDH1 / E Cadherin Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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