| 产品详情 |
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| Product Name | T4 Endonuclease V |
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| Description | Applications Study of UV damage to DNA and its repair, including DNA damage in single cells. Detection of differential UV damage repair of transcribed sequences. Detection of UV mutational hotspots. T4 Endonuclease V functions as part of a base excision repair pathway to recognize and remove cyclobutane pyrimidine dimers. The enzyme binds to UV-irradiated DNA and processively scans the DNA until a pyrimidine dimer is encountered. T4 Endonuclease V then cleaves the glycosyl bond of the 5'-pyrimidine of the dimer and the 3' phosphodiester bond, resulting in breakage of the DNA strand.1,2 Strand breakage is evident during subsequent electrophoresis as a change in conformation (i.e., from covalent closed circular to relaxed circular molecules), or as the appearance of unique DNA fragments. The enzyme is a small protein that does not require divalent cations or other cofactors.1 Source: gene denV in E. coli Activity: 20u/ul Unit Definition: One unit will change 1ug of UV-irradiated plasmid |
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| Size | 100U, 500U |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | gene denV in E. coli |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | T0200 |
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| Order / More Info | T4 Endonuclease V from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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