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| Product Name | Novel Inducer of Death-1, NID-1 ((E)-N-(2-ethylphenyl)-3-(5-nitrothiophen-2-yl)acrylamide) |
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| Description | Purity ~98% (HPLC). A cell-permeable, nitrothiophenylpropenamide compound that induces active, energy-dependent, and rapid non-apoptotic cell death (EC50 = 1.65uM) in several transformed (DRD, RKO, H1299) and non-transformed (BJeH) human cells, in a variety of cancer cell lines, and in mouse embryonic fibroblasts. The cell death appears to be non-necrotic, non-oxidative and is independent of DNA damage or cell proliferation. NID-1 induced cell death, although distinct from macroautophagy, does show PI 3-kinase suppression, ATG5-dependence, p62 degradation, and higher LC3 levels. Also, NID-1-induced death is independent of caspases, Bax and Bak and requires lysosomal activity and cytosolic vacuolization. Rescues mutant-huntingtin-induced cell death in a cell-based model of Huntington's disease. Shown to increase cathepsin L levels, but does not affect cathepsins B, C, and H. Solubility: DMSO |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217598 |
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| Order / More Info | Novel Inducer of Death-1, NID-1 ((E)-N-(2-ethylphenyl)-3-(5-nitrothiophen-2-yl)acrylamide) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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