| 产品详情 |
| Edit |   |
|---|
| Product Name | Tumor Necrosis Factor Receptor Superfamily Member 11B, active (TNFRSF11B), Recombinant, Human |
|---|
| Description | Purity ≥95% as determined by SDS-PAGE and HPLC. Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is <10ng/ml, corresponding to a specific activity of 1x10e5IU/mg in the presence of 10ng/mL soluble rHuRANKL (sRANKL). |
|---|
| Size | 10ug, 50ug, 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Osteoclastogenesis inhibitory factor |
|---|
| Gene, Accession, CAS # | TR11B_HUMAN, SwissProt: O00300 |
|---|
| Catalog # | 348254 |
|---|
| Price | |
|---|
| Order / More Info | Tumor Necrosis Factor Receptor Superfamily Member 11B, active (TNFRSF11B), Recombinant, Human from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|