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| Product Name | HAAO, Recombinant, Human, aa1-286, His-Tag |
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| Description | Purity ~90% (SDS-PAGE). HAAO is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. This protein catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Source: Recombinant corresponding to aa1-286 from human HAAO, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~35kD (310aa) confirmed by MALDI-TOF AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMERRLG VRAWVKENRG SFQPPVCNKL MHQEQLKVMF IGGPNTRKDY HIEEGEEVFY QLEGDMVLRV LEQGKHRDVV IRQGEIFLLP ARVPHSPQRF ANTVGLVVER RRLETELDGL RYYVGDTMDV LFEKWFYCKD LGTQLAPIIQ EFFSSEQYRT GKPIPDQLLK EPPFPLSTRS IMEPMSLDAW LDSHHRELQA |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HAAO, Recombinant, Human, aa1-286, His-Tag (3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate Oxygenase, 3-HAO, 3-hydroxyanthranilic Acid Dioxygenase, HAD) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 45432 |
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| Order / More Info | HAAO, Recombinant, Human, aa1-286, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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