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| Product Name | SNX3, Recombinant, Human, aa3-162, GST-Tag (Sorting Nexin-3) |
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| Description | Purity ~90% (SDS-PAGE). Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling o |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Protein SDP3 |
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| Gene, Accession, CAS # | SwissProt: O60493 |
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| Catalog # | 375364 |
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| Order / More Info | SNX3, Recombinant, Human, aa3-162, GST-Tag (Sorting Nexin-3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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