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| Product Name | CCND1, Recombinant, Human, aa1-295, His-Tag (G1/S-specific Cyclin-D1) |
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| Description | Purity ~90% (SDS-PAGE). Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. Source: Recombinant protein corresponding to aa1-295 |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P24385 |
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| Catalog # | 372645 |
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| Order / More Info | CCND1, Recombinant, Human, aa1-295, His-Tag (G1/S-specific Cyclin-D1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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