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| Product Name | TLR-3, Recombinant, Human (Toll-like receptor 3, CD283 antigen) |
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| Description | Purity ≥95% by SDS-PAGE gel and HPLC analyses. TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-kappaB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.4kD glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain. Biological Activity: Determined by its ability to inhibit IL-8 secretion induced b |
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| Size | 5ug, 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143526 |
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| Order / More Info | TLR-3, Recombinant, Human (Toll-like receptor 3, CD283 antigen) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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