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| Product Name | Plasminogen Activator (tPA) BioAssay™ ELISA Kit (Antibodies only) |
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| Description | Tissue-type plasminogen activator (tPA) is one of two major physiologic activators of plasminogen in plasma. It is a serine protease of 68 kDa produced primarily in endothelial cells but is also present in monocytes and megakaryocytes. Normal plasma tPA antigen concentrations have been reported from 20ng/ml to 5ug/ml, depending on the assay used, but typically most of the tPA (>90%) is in complex with it's primary inhibitor, plasminogen activator inhibitor-1 (PAI-1). Structurally, tPA is a single-chain enzyme that consists of a catalytic domain followed by two kringle structures, an EGF domain and a finger domain. The activation of plasminogen by tPA is dependent on the presence of a fibrin cofactor. The binding of both tPA and plasminogen to fibrin is mediated in part through lysine binding sites within the kringle structures of both enzyme and substrate, but also through the finger domain of tPA. Activation of plasminogen by tPA occurs by cleavage after residue Arg560 to produce the |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P4256-33 |
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| Price | |
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| Order / More Info | Plasminogen Activator (tPA) BioAssay™ ELISA Kit (Antibodies only) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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