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| Product Name | NR2F6, Recombinant, Human, aa1-404, His-SUMO-Tag (Nuclear Receptor Subfamily 2 Group F Member 6) |
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| Description | Purity ~90% (SDS-PAGE). Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P10588 |
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| Catalog # | 374468 |
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| Order / More Info | NR2F6, Recombinant, Human, aa1-404, His-SUMO-Tag (Nuclear Receptor Subfamily 2 Group F Member 6) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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