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| Product Name | MK-2206 |
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| Description | Purity ~98% (HPLC). A highly selective non-ATP competitive allosteric Akt inhibitor with IC50's of 8nM, 2nM and 65nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr308 and Ser473 in 3T3-L1 adipocytes with IC50 values of 0.11 and 0.18uM, respectively as well as downstream effects of insulin on GLUT4 translocation (IC50 = 0.47uM) and glucose transport (IC50 = 0.14uM). In addition, treatment with MK-2206 causes a robust, concentration-dependent activation of autophagy in human glioma cell lines LN229 and T98G. Solubility: DMSO |
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| Size | 500ug, 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MK-2206 (8-(4-(1-Aminocyclobutyl)phenyl-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one Dihydrochloride) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | M4095-40 |
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| Price | |
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| Order / More Info | MK-2206 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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