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| Product Name | Amyloid Precursor Protein, NT (APP, Amyloid beta (A4) Precursor Protein), Blocking Peptide |
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| Description | Purity ~60-70%. Peptide (linear) corresponding to amino acids 653 to 662 of human amyloid A4 protein precursor (APP) (1) or aa1-10 of the 4kD Ab peptide generated by b- and g-secretases (2). The peptide sequences are identical to those of rabbit, pig, bovine, guinea pig, and chicken. Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimer's disease patients and Downs's Syndrome patients. In Alzheimer's disease, thi |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | A4, AAA, ABETA, ABPP, AD1, Alzheimer disease amyloid protein, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease), Amyloid beta A4 protein precursor, APPI, Cerebral vascular amyloid peptide, CTFgamma, CVAP, PN2, PN-II, PreA4, Protease nexin-II |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A2275-87A |
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| Order / More Info | Amyloid Precursor Protein, NT (APP, Amyloid beta (A4) Precursor Protein), Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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