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| Product Name | IL-12 (p40) BioAssay™ ELISA Kit, Human |
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| Description | Interleukin-12 (IL12; formerly NKSF, for natural killer cell stimulatory factor, or CLMF, for cytotoxic lymphocyte maturation factor) is a novel cytokine cloned from B-cell lines. IL-12 is a heterodimeric molecule composed of p35 and p40 subunits (1). The larger 40kD subunit (p40) is a member of the cytokine receptor family, and the smaller 35kD subunit (p35) is related to IL-6 and GCSF (2). Both IL-12 p40(-/-) and p35(-/-) mice fail to produce IL-12 p70 heterodimer (3). Interleukin (IL)-12 has been cloned on the basis of its ability to activate natural killer (NK) cells and promote the development of cytolytic T cells. With further understanding of its activities, IL-12 has emerged as an important cytokine, affecting both immune and hematologic functions. It has been shown to be necessary for the T cell independent induction of interferon (IFN)-gamma, critical for the initial suppression of bacterial and parasitic infection; for the development of a Th1 response, critical for effectiv |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 3593, SwissProt: P29460 |
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| Catalog # | 143891 |
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| Order / More Info | IL-12 (p40) BioAssay™ ELISA Kit, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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