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| Product Name | TMEM16A Activator, Eact |
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| Description | Purity ~98% (HPLC). An N-aroylaminothiazole that strongly activates TMEM16A (ANO1) calcium-activated chloride channel (CaCC) at 0 Ca2+ concentration (Ca2+ independent), with the capability of producing large and sustained CaCC Cl-1 currents (EC50=3uM) in TMEM16A-expressing Fisher Rat Thyroid (FRT) Cells without elevation of cytoplasmic Ca2+ level, and in human A253 cells. Shown to increase CaCC conductance in human salivary and airway submucosal gland epithelial cells, IL-4 treated bronchial cells, and stimulated submucosal gland secretion in human bronchi and smooth muscle contraction in mouse intestine. Activation effect can be abolished by the addition of a TMEM16A inhibitor T16A-A01 at 10uM in TMEM16A-transfected cells and in cultures of human salivary gland and IL-4-treated bronchial epithelia, but not in intestine. Does not affect CFTR Cl- conductance or ENaC Na+ conductance. Formula: C22H24N2O5S Molecular Weight: 428.5 Solubility: DMSO (100mg/ml, clear, colorless solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TMEM16A Activator, Eact (3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenylthiazol-2-yl)benzamide, ANO1 Activator) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217839 |
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| Order / More Info | TMEM16A Activator, Eact from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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