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| Product Name | Tankyrase, Human (TRF1 interacting ankyrin-related ADP-ribose polymerase) (Control Peptide) |
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| Description | Highly purified. A 21aa Peptide sequence near the C-terminus of human tankyrase. The 3'ends of chromosomes are capped with telomere sequences (TTAGGG; 6-26 nucleotides in length) by ribonucleoprotein telomerase during DNA replication. 4.8 kb of telomeric DNA is lost with each cell division. Telomere length is maintained by regulating the activity of telomerase. Purification of telomerase from the ciliate also revealed two protein of 43 and 123kD. p123 is a homolog of yeast Est2 (Essential for Telomerase activity) and show 20% homology. Mammalian homologs of yeast Est2 (also known as TP2 for Telomerase associated Protein 2; hEST2 or telomerase catalytic subunit or telomerase reverse transcriptase, TERT) have also been cloned (human Est2, 1132 aa; ~127kD). hEST2 was localized in the nucleus. It is associated with telomerase activity and TP1. Telomeric Repeat binding Factors (TRF1 and TRF2) bind the telomeric TTAGGG repeat. TRFs have been colocalized with telomeric DNA in metaphase cells. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | T0900-15 |
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| Order / More Info | Tankyrase, Human (TRF1 interacting ankyrin-related ADP-ribose polymerase) (Control Peptide) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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